A mouse model for HIV-1 entry

A mouse model for HIV-1 entry.

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically human...

Immunogenicity of a New HIV-1 DNA Construct in a BALB/c Mouse Model

Background: Cell mediated immunity, especially cytotoxic T cell responses against HIV-1 infection, plays a critical role in controlling viral replication and disease progres-sion. DNA vaccine is a novel technology which is known to stimulate strong cellular immune responses. Many DNA vaccines have been tested for HIV infection but there is still no effective vaccine against this infection. Cons...

immunogenicity of a new hiv-1 dna construct in a balb/c mouse model

background: cell mediated immunity, especially cytotoxic t cell responses against hiv-1 infection, plays a critical role in controlling viral replication and disease progres-sion. dna vaccine is a novel technology which is known to stimulate strong cellular immune responses. many dna vaccines have been tested for hiv infection but there is still no effective vaccine against this infection. cons...

Endocytic entry of HIV-1

Enveloped viruses enter target cells by membrane fusion or endocytosis. In the latter case, fusion of the viral envelope is induced by the acidic pH of the endocytic vesicle [1]. As with most other retroviruses, entry of the human immunodeficiency virus (HIV) is thought to be exclusively by pH-independent membrane fusion after interaction of its envelope with CD4 and a chemokine co-receptor on ...

Promoter Activity of CXCR4, a Coreceptor for HIV-1 Entry